• L-methylfolate (Deplin, MethylPro) is a form of folate that supports
brain function by aiding in the production of neurotransmitters like
serotonin, norepinephrine, and dopamine, which influence mood.
Many individuals with depression have difficulty producing enough
L-methylfolate, which may impair their response to antidepressants.
L-methylfolate itself is not an antidepressant but helps enhance the
effectiveness of antidepressant treatments. It is particularly
effective for those with depression who are overweight (BMI > 30).
• Several factors can prevent sufficient production of L-methylfolate,
including genetic variations (such as the MTHFR c-677t gene),
aging, certain illnesses (e.g., diabetes, Crohn’s disease), poor
lifestyle choices (e.g., smoking, excessive alcohol), and some
medications (e.g., seizure drugs, methotrexate, oral contraceptives).
• L-methylfolate is typically taken once a day, with or without food,
and benefits are usually seen within 2-4 weeks. It should not be
taken with regular folate supplements, as they may interfere with its
absorption in the brain. Side effects are rare, with 96% of people
finding it well-tolerated, and it has been shown to reduce
antidepressant side effects without causing weight gain, fatigue,
insomnia, or sexual dysfunction.
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