L-Methylfolate

• L-methylfolate (Deplin, MethylPro) is a form of folate that supports

brain function by aiding in the production of neurotransmitters like

serotonin, norepinephrine, and dopamine, which influence mood.

Many individuals with depression have difficulty producing enough

L-methylfolate, which may impair their response to antidepressants.

L-methylfolate itself is not an antidepressant but helps enhance the

effectiveness of antidepressant treatments. It is particularly

effective for those with depression who are overweight (BMI > 30).

• Several factors can prevent sufficient production of L-methylfolate,

including genetic variations (such as the MTHFR c-677t gene),

aging, certain illnesses (e.g., diabetes, Crohn’s disease), poor

lifestyle choices (e.g., smoking, excessive alcohol), and some

medications (e.g., seizure drugs, methotrexate, oral contraceptives).

• L-methylfolate is typically taken once a day, with or without food,

and benefits are usually seen within 2-4 weeks. It should not be

taken with regular folate supplements, as they may interfere with its

absorption in the brain. Side effects are rare, with 96% of people

finding it well-tolerated, and it has been shown to reduce

antidepressant side effects without causing weight gain, fatigue,

insomnia, or sexual dysfunction.

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